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Real-time imaging of hepatitis C virus
Letter by Jones et al.Hepatitis C virus research is hampered by the inability to detect individual infected cells. Jones et al. achieve this by imaging the translocation of a fluorescent reporter protein after cleavage by a viral protease in living or fixed cells.
Advance Online Publication
Reconfiguring energy metabolism
Article by Gohil et al.Many diseases are characterized by shifts in cellular energy metabolism. Gohil et al. use a quantitative, nutrient-sensitized screen to identify drugs that affect the relative rates of glycolysis and mitochondrial respiration, and demonstrate the protective capacity of an approved antiemetic in models of cardiac and cerebral ischemia.
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Internet exchanges suggest an easy route to sourcing and licensing technology, but can biotech intellectual property be packaged up and sold in this way?
Current Issue
HER2 testing conundrum
News Feature by AllisonFREEProblems in interpreting diagnostic tests for HER2 may be compromising patient access to effective treatments. As new versions of therapies targeting HER2 work their way through clinical trials, will the situation get even murkier?
Current Issue
Potent siRNA delivery
Letter by Semple et al.Efficient siRNA delivery remains a key challenge to realizing the full potential of RNAi-based therapeutics. Semple et al. accomplish unprecedented potency for liposome-mediated siRNA delivery by applying rational design to refine an empirically identified cationic lipid widely regarded as the benchmark for use in lipid nanoparticles.
Advance Online Publication
Inducing cell cycle entry in AML
Letter by Saito et al.In acute myeloid leukemia, a sub-population of quiescent cancer cells, called leukemia stem cells, is thought to be responsible for chemotherapy resistance and eventual recurrence of the disease. Saito et al. show that treatment with granulocyte colony-stimulating factor can overcome resistance to standard therapy by inducing cell cycle entry of the leukemia stem cells.
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Lee et al. have created the largest functional gene network for plants by combining existing data onArabidopsis thaliana with data gathered from other organisms. Although the genetics of many A. thaliana traits has been thoroughly studied, the authors succeed in discovering new genes associated with root development and drought resistance.
